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Virus Production and Manipulation of Protein/Gene Expression (VPMP) module

The VPMP module is a redesign of the former Molecular Biology module. A survey of participating faculty indicated a strong interest in focusing this module on the development and production of virus particles, including lentivirus, herpes, adenovirus, and adeno-associated virus (AAV), and the resources needed for virus and protein purification. The virus particles could be developed for a number of applications, including the development of stable cell lines, CRISPR screens, or for the purpose of gene therapy vectors in animal studies. Most labs in the Department are now using viruses as tools to manipulate gene expression in cell cultures, organoids, and animals. The VPMP module will accelerate these studies by providing routine services. Still, other investigators, for example, cortical vision faculty, expressed an interest in using AAV vectors for optogenetic studies but have not yet done so because of a lack of molecular expertise. The VPMP module fulfills this need by providing expertise in virus production and purification for animal studies.