Optic Nerve Regeneration Laboratory

Takaaki Kuwajima, PhD
Research Assistant Professor of Ophthalmology
Universitry of Pittsburgh School of Medicine

Member of the Louis J. Fox Center for Vision Restoration


Lab Personnel
Gregory Campbell, Research  Technician

Dwarkesh Amin, Undergraduate Student

Sneha Misra, Undergraduate Student


Research Interests

  • Optic nerve regeneration
  • Optic nerve degeneration
  • Retinal axon injury
  • Glaucoma
  • Retinal axon development


Representative Publications

  1. Kuwajima T, Mason C (2017) Live or Die? Depends Who You Are Neuron 94 (6):1043-1045
  2. Kuwajima T**, Celia S, Sitko AA, Lefebvre V, Mason C** (2017) SoxC transcription factors promote contralateral retinal ganglion cell differentiation and axon guidance in the mouse visual system. Neuron 93 (5):1110-1125 [** corresponding authors]
  3. Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B, Henderson CE (2016) Protein prenylation constitutes an endogenous brake on axonal growth. Cell Reports 16(2):545-558
  4. Kuwajima T, Sitko AA, Bhansali P, Jurgens C, Guido W, Mason C (2013) ClearT: a detergent- and solvent-free clearing method for visualizing neuronal and non- neuronal tissues. Development 140 (6):1364-1368
  5. Kuwajima T, Yoshida Y, Takegahara N, Petros TJ, Kumanogoh A, Jessell TM, Sakurai, T, Mason C (2012) Optic chiasm presentation of Semaphorin6D in the context with Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron 74 (4):676-690
  6. Kuwajima T*, Hasegawa K*, Yoshikawa K (2010) Necdin promotes tangential migration of neocortical interneurons from basal forebrain. Journal of Neuroscience 30 (10):3709-3714 [*equal contribution to this work]
  7. Kuwajima T, Nishimura I, Yoshikawa K (2006) Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. Journal of Neuroscience 26 (20):5383-5392


Contact Information

Takaa Kuwajimi, PhD
BST3 10014A
Pittsburgh, PA 15213