Advanced Ophthalmic Imaging Laboratory

Principal Investigator

Ethan A. Rossi, PhD
Assistant Professor
Department of Ophthalmology
University of Pittsburgh School of Medicine

Lab Personnel

Elena Gofas Salas, PhD, Postdoctoral Associate
Valerie Snyder Ophthalmic Imaging Specialist
Min Zhang, PhD, Software Engineer

Research Interests

Our research focuses on developing and deploying high resolution imaging tools, such as adaptive optics ophthalmoscopy, to study the structure and function of the normal and diseased retina on a microscopic scale in the living human eye. Current research in the advanced ophthalmic imaging laboratory is organized around two major arms focused on glaucoma and age-related macular degeneration. Our AMD work involves studying the association between genotype, retinal phenotype and risk for progression to advanced AMD. Our glaucoma studies are focused on refining new imaging tools for imaging retinal ganglion cells and deploying them to study the changes to retinal ganglion cells that accompany glaucoma onset, progression and response to treatment. Additional research interests include eye movements, visual performance and image processing.

Select Publications

Rossi EA, Granger CE, Sharma R, Yang Q, Saito K, Schwarz C, Walters S, Nozato K, Zhang J, Kawakami T, Fischer W, Latchney LR, Hunter JJ, Chung MM, Williams DR. Imaging individual neurons in the retinal ganglion cell layer of the living eye. Proceedings of the National Academy of Sciences. 2017 114 (3) 586-591; published ahead of print January 3, 2017, doi:10.1073/pnas.1613445114

Song H, Rossi EA, Stone E, Latchney LR, Williams DR, Dubra A, Chung MM. Adaptive optics demonstrates phenotypic diversity in autosomal dominant cone rod dystrophy associated with a single mutation in the GUCA1A gene. British Journal of Ophthalmology. Accepted for publication 8/14/2017.

Williams ZW, Rossi EA, DiLoreto DA. In vivo adaptive optics ophthalmoscopy correlated with histopathology in cancer associated retinopathy. Ophthalmology Retina. Published online Sept. 9, 2017, doi: 10.1016/j.oret.2017.06.008

Song H, Rossi EA, Latchney L, Bessette A, Stone E, Hunter JJ, Williams DR, Chung M. Cone and rod loss in Stargardt disease revealed by adaptive optics scanning light ophthalmoscopy. JAMA Ophthalmology. 2015 Oct;133(10):1198–203.

Zhang J, Yang Q, Saito K, Nozato K, Roorda A, Williams DR, Rossi EA. An adaptive optics imaging system designed for clinical use. Biomedical Optics Express. 2015 Jun 1;6(6):2120.

Yang Q, Zhang J, Nozato K, Saito K, Williams DR, Roorda A, Rossi EA. Closed-loop optical stabilization and digital image registration in adaptive optics scanning light ophthalmoscopy. Biomedical Optics Express. 2014 Sep 1;5(9):3174.

Rossi EA, Rangel-Fonseca P, Parkins K, Fischer W, Latchney LR, Folwell MA, Williams DR, Dubra A, Chung MM. In vivo imaging of retinal pigment epithelium cells in age related macular degeneration. Biomedical Optics Express. 2013 Nov 1;4(11):2527–39.

Rossi EA, Roorda A. The relationship between visual resolution and cone spacing in the human fovea. Nature Neuroscience. 2010 Feb;13(2):156–7.

Funding Support

BrightFocus Foundation
Edward N. & Della L. Thome Memorial Foundation

Contact Information

Ethan A. Rossi PhD
Eye & Ear Institute, Suite 834
203 Lothrop Street
Pittsburgh, PA 15213