Yiqin Du, MD, PhD

  • Associate Professor of Ophthalmology
  • Associate Professor of Developmental Biology
  • University of Pittsburgh School of Medicine

Academic Affiliation

1992-1997 Attending Ophthalmologist Department of Ophthalmology, Xuzhou Third Hospital, Xuzhou, China 

2001-2003 Associate Professor Department of Ophthalmology, Xuzhou Third Hospital, Xuzhou, China ; Post-doctoral fellow, Beijing University, Beijing, China.

2008-2013 Research Assistant Professor, Departments of Ophthalmology & Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh PA USA

2013-2016 Assistant Professor, Department of Ophthalmology & Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh PA USA

2016-present Associate Professor, Department of Ophthalmology & Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh PA USA

Education & Training

  • Xuzhou Medical College, Jiangsu Province, China, Clinical Medicine, M.D.
  • Beijing University, Beijing, China, Ophthalmology, Ph.D.

Representative Publications

  1. Yiqin Du*, Jing Chen, James L Funderburgh, Xiuan Zhu, Lingsong Li. Functional reconstruction of rabbit corneal epithelium by human limbal cells cultured on amniotic membrane. (*: Corresponding author). Mol Vis. 2003; 9:635-643. PMID: 14685149.
  2. Yiqin Du, Martha L Funderburgh, Mary M Mann, Nirmala SundarRaj, James L Funderburgh. Multipotent Stem Cells in Human Corneal Stroma. Stem Cells. 2005; 23: 1266-1275. PMID: 16059757.
  3. Yanling Ma, Yongsheng Xu, Zhifeng Xiao, Wei Yang, Chun Zhang, E Song, Yiqin Du, Lingsong Li. Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells. 2006; 24: 315 - 321. PMID: 16109757.
  4. Yiqin Du, Nirmala Sundarraj, Martha L. Funderburgh, Stephen A. Harvey, David E. Birk, James L. Funderburgh. Secretion and Organization of a Cornea-like Tissue in vitro by Stem Cells from Human Corneal Stroma. Invest. Ophthalmol. Vis. Sci. 2007; 48: 5038-5045. PMID: 17962455.
  5. Yiqin Du, Eric Carlson, Martha L. Funderburgh, Naxin Guo, David E. Birk, Winston W. Kao, James L. Funderburgh. Stem Cell Therapy Restores Transparency to Defective Murine Corneas. Stem Cells. 2009, 27 (7): 1635-1642. PMID: 19544455.
  6. Yiqin Du, Danny Roh, Martha Funderburgh, Mary Mann, Kacey Marra, Peter Rubin, Xuan Li, James Funderburgh. Adipose-Derived Stem Cells Differentiate to Keratocytes in vitro. Mol. Vis. 2010; 16:2680-2689. PMID: 21179234.
  7. Yiqin Du*, Danny S. Roh, Mary M. Mann, Martha L. Funderburgh, James L. Funderburgh, Joel S. Schuman. Multiple stem cells from trabecular meshwork become phagocytic TM cells. (*: Corresponding author). Invest. Ophthalmol. Vis. Sci. 2012; 53 (3): 1566-1575. PMID: 22297497.
  8. Craig Boote*, Yiqin Du*, Sian R. Morgan , Jonathan Harris , Christina S. Kamma-Lorger , Sally Hayes , Kira L. Lathrop, Danny S. Roh, Michael K. Burrow, Jennifer Hiller , Nicholas J. Terrill , James L. Funderburgh, Keith M. Meek. Quantitative Assessment of Ultrastructure and Light Scatter in Mouse Corneal Debridement Wounds. (*Co-first author). Invest. Ophthalmol. Vis. Sci. 2012; 53 (6): 2786-2795. PMID: 22467580.
  9. Yiqin Du*, Hongmin Yun, Enzhi Yang, Joel S. Schuman. Stem cells from trabecular meshwork can home to the TM region in vivo. (*: Corresponding author). Invest. Ophthalmol. Vis. Sci. 2013; 54 (2): 1450-1459. PMID: 23341019.
  10. Sayan Basu, Andrew J. Hertsenberg, Martha L. Funderburgh, Michael K. Burrow, Mary M. Mann, Yiqin Du, Kira L. Lathrop, Fatima N. Syed-Picard, Sheila M. Adams, David E. Birk, James L. Funderburgh. Human limbal biopsy–derived stromal stem cells prevent corneal scarring. Sci. Transl. Med. 2014; 6: 266ra172.
  11. Hongmin Yun, Kira L. Lathrop, Enzhi Yang, Ming Sun, Larry Kagemann, Valeria Fu, Donna B. Stolz, Joel S. Schuman, Yiqin Du*. A Laser-Induced Mouse Model with Long-Term Intraocular Pressure Elevation. (*: Corresponding author). Plos One. 2014; 9(9): e107446. Doi:10.1371/journal.pone.0107446. PMID: 25216052.
  12. James L. Funderburgh, Martha L. Funderburgh, Yiqin Du. Stem Cells in the Limbal Stroma. Ocular Surface. pii: S1542-0124(16)00007-0. doi: 10.1016/j.jtos.2015.12.006. PMID: 25504883.
  13. Hongmin Yun, Yi Zhou, Andrew Wills, Yiqin Du*. Stem Cells in the Trabecular meshwork for Regulating Intraocular Pressure. (*: Corresponding author).  J Ocul Pharmacol Ther. 2016 32(5): 253-60. PMID: 27183473.
  14. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Keller, Kate E; Bhattacharya, Sanjoy K; Borras, Theresa; Brunner, Thomas M; Chansangpetch, Sunee; Clark, Abbott F; Dismuke, W Michael; Du, Yiqin; Elliott, Michael H; Ethier, C Ross; Faralli, Jennifer A; Freddo, Thomas F; Fuchshofer, Rudolf; Giovingo, Michael; Gong, Haiyan; Gonzalez, Pedro; Huang, Alex; Johnstone, Murray A; Kaufman, Paul L; Kelley, Mary J; Knepper, Paul A; Kopczynski, Casey C; Kuchtey, John G; Kuchtey, Rachel W; Kuehn, Markus H; Lieberman, Raquel L; Lin, Shan C; Liton, Paloma; Liu, Yutao; Lutjen-Drecoll, Elke; Mao, Weiming; Masis-Solano, Marisse; McDonnell, Fiona; McDowell, Colleen M; Overby, Darryl R; Pattabiraman, Padmanabhan P; Raghunathan, Vijay K; Rao, P Vasanth; Rhee, Douglas J; Chowdhury, Uttio Roy; Russell, Paul; Samples, John R; Schwartz, Donald; Stubbs, Evan B; Tamm, Ernst R; Tan, James C; Toris, Carol B; Torrejon, Karen Y; Vranka, Janice A; Wirtz, Mary K; Yorio, Thomas; Zhang, Jie; Zode, Gulab S; Fautsch, Michael P; Peters, Donna M; Acott, Ted S; Stamer, W Daniel. Experimental eye research. 2018, Mar 9. 171:164-173. PMID: 29526795.
  15. Ajay Kumar, Yi Xu, Enzhi Yang, Yiqin Du*. Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Secretome after Long Term Storage-Potential Implications for Ocular Regeneration. (*: Corresponding author). Invest. Ophthalmol. Vis. Sci. 2018, 59: 3728-38. PMID: 30046814.
  16. Hongmin Yun, Yiwen Wang, Yi Zhou, Ke Wang, Ming Sun, Donna B. Stolz, Xiaobo Xia, C. Ross Ethier, Yiqin Du*. Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model. (*: Corresponding author). Communications Biology, (2018) 1:216 | DOI: 10.1038/s42003-018-0227-z. eCollection 2018. PMID: 30534608.
  17. Yiwen Wang, Deborah Osakue, Enzhi Yang, Yi Zhou, Haiyan Gong, Xiaobo Xia, Yiqin Du*. ER Stress Response of Trabecular Meshwork Stem Cells and TM Cells and Protective Effects of Activated PERK Pathway. (*: Corresponding author). Invest. Ophthalmol. Vis. Sci.  2019, 60(1): 265-73. PMID: 30654386.
  18. Alexander Castro, Yiqin Du*. Trabecular Meshwork Regeneration - A Potential Treatment for Glaucoma. (*: Corresponding author). Curr. Ophthalmol. Rep. Invited review. 2019, https://doi.org/10.1007/s40135-019-00203-2.

Research Interests

Stem Cell Biology & Glaucoma